The best laid plans o’mice and researchers: my top 5 chance scientific discoveries.

Most scientists are rarely content until they can say that they have planned for all eventualities. But no matter how hard you try, lab work will often throw you a curve ball, turning up all manner of unexpected curiosities. Yes, it’s true the “best laid plans o’mice and researchers gang aft a gley”*! However, there is no need to despair, for buried in the annals of scientific literature are a number of compelling tales where odd results and downright stupidity have actually lead to some pretty ground-breaking discoveries. So, here are five of my favorite examples of scientific serendipity.

5) The artificial pacemaker:

The first implantable pacemaker

The first implantable pacemaker

The first implantable pacemaker was invented and developed by electrical engineer and prolific inventor Wilson Greatbatch. But this is no ordinary tale of academic prowess. Unfortunate and clumsy scientists can take heart to learn that, despite Greatbatch’s impressive academic repertoire, it was actually a technical mistake which lead him towards this life-saving invention.

In 1956, Greatbatch was working on a device to record heart-rhythms when he accidentally connected an incorrect electrical component (for the geeky this was an ill-fitting resistor). This mistake meant that his device actually emitted electrical activity instead of recording it.  Greatbatch worked on miniaturising and testing his creation and by 1960 the first artificial pacemaker was implanted into a human patient. The recipient, a 77  year old man  went on to live for a further 18 months.

This is a great example of when a technical error actually translated into a ground-breaking discovery. But be careful, 99% of the time such mistakes are still significantly more likely to end in blown fuses and angry screaming than medical breakthroughs!

4) The discovery of penicillin.

Alexander Fleming

Alexander Fleming

No list of accidental scientific discoveries could be complete without the tale of Alexander Fleming’s discovery of penicillin. Fleming, who at the time was described as a careless lab technician (charming), returned from holiday to find that one of his badly tended experiments had grown mould. Although in this instance, his inability to maintain a sterile work environment actually revolutionised modern medicine.

Fleming noticed that the Staphylococcus bacteria  in this particular sample did not grow around the mould. Indeed he noted that the Staphylococcus colonies became transparent and were obviously dying.  The mould was soon identified as a rare strain of Penicillium notatum, which appeared to secrete a compound capable of stopping bacterial growth. In fact Fleming’s mucky lab practices had lead him to stumble upon the first known antibiotic – a discovery which has since changed the course of medicine and allowed for previously life-threatening diseases to be completely curable.

Fleming himself is quoted as saying: “One sometimes finds what one is not looking for. When I woke up just after dawn on Sept. 28, 1928, I certainly didn’t plan to revolutionize all medicine by discovering the world’s first antibiotic, or bacteria killer. But I guess that was exactly what I did” (he was obviously a humble chap).

3) Cosmic background radiation.

IMGP0003Any scientist can tell you how annoying inconsistent or noisy data can be, but not many could boast that noise actually won them a Nobel Prize.

In 1965, Arno A. Penzias and Robert W. Wilson were working for Bell Laboratories using a sensitive horn antenna to detect low levels of microwave radiation. As they scanned the sky with this device their findings were constantly overshadowed by a low level of background “noise”. Both scientists assumed that this persistent “noise” was an unwanted artifact and tried a huge range of techniques to eliminate it but their attempts were to no avail. However, after much head-scratching they finally discovered that another group of scientists from Princeton had already predicted that such “noise” should be detectable as a remnant from the Big Bang and were about to start looking for this themselves.

So it turned out that the annoying artifact that Penzias and Wilson spent so much time trying to eliminate was actually background radiation left over from the Big BangIf only experimental noise was always this interesting!

2) Drunk scientists discover wine improves super conductance

A wine label only a scientist could love!Contrary to the popular mathematician’s saying ‘don’t drink and derive’, it seems that, in some cases, a little bit of alcohol (or perhaps a lot) can actually facilitate scientific discovery.

A few years ago, scientists at Japan’s National Institute for Materials Science got a little bit tipsy at an office party and, instead of stealing office supplies, they decided to head back to the lab and do a few unauthorised experiments.

Their lab was working to develop a new type of superconductor by soaking a compound in hot water and ethanol for several hours. But, after a few drinks, one bright spark decided that it would be much more fun to see what happened when they instead soaked this compound in whatever left-over booze they could find from the party.

Amazingly the next morning, alongside the customary hangover, the researchers also discovered that commercially available alcohol seemed significantly better at improving super conductance than anything they would commonly use in the lab. Indeed, using lab- grade ethanol improved the material’s superconductivity by about 15%, while red wine improved it by almost 65%. These results were certainly not expected but were, without doubt, a big step forward for these scientists – I think it may be time for another party!

1) Common worming tablet inhibits growth of cancer cells.

3667927147_e452ddc04eScientists from Johns Hopkins University’s East Baltimore medical campus were left scratching their heads a few years ago when techniques used to grow tumors in mice failed to work on one particular group of research animals. After a number of failed attempts, the researchers decided that there was something kooky about these mice and set about finding what it was.

It turned out that these specific mice had been treated with a cheap, mass-produced, medication used to prevent pinworm infections and that this had been preventing tumor growth in these animals. Spurred on by this unexpected breakthrough, researchers soon found that a related drug – mebendazole – was particularly effective at treating an aggressive type of brain tumor (glioblastoma multiforme).

Years down the line and new drugs, stemming from this unexpected discovery, are now being trialed on terminally ill cancer patients with the hope that this will lead to more widespread use.

So there you have it. If you want to be a top-notch scientist remember that keeping your workspace sterile is totally overrated, regular office parties are a must and don’t forget to love your noise – you never know where it may lead you.

Post by: Sarah Fox
*Often go awry.

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Heretic to hero: Sir Harold Ridley and his sight-saving invention

It’s a strange phenomenon that some of the most revolutionarily successful people are initially rejected, scorned or unappreciated. Galileo, van Gogh, Darwin, Lovelace, Mendel and Austen were all vastly unpopular in their time, yet now we all take their scientific and creative contributions for granted. Sir Harold Ridley, the inventor of the intraocular lens, is another example of these late-sung heroes. His work saves the eyesight of millions of people across the world every year, but at first his idea of placing a plastic lens onto the surface of the eye was thought by peers to be impossible, laughable and even dangerous.

Cataract in a human eye. The pupil looks milky or cloudy. Image from Rajesh Ahuja, MD, Wikicommons.

The eyeball acts like a camera: light from the outside travels through the pupil and the lens to focus on the back of the eye, where the light is translated into images by light-sensitive cells that are located there. Due to age, trauma, toxic chemicals or certain diseases such as rubella or diabetes, the proteins that make up the lens denature and become opaque which prevents light from entering the eye and causes cataracts. People with cataracts suffer from very poor vision or blindness (see the image comparison); over half the world’s blindness (around 20 million people) is caused by age-related cataracts alone.

Normal vision. Image from National Eye Institute, NIH, Wikicommons.

Sight with cataracts: the image is blurry or out of focus, . Image from National Eye Institute, NIH, Wikicommons.

 

 

 

 

 

 

 

Over the course of history, several gory approaches to treating cataracts have been trialled. Somewhere between 2000-600BC, a procedure called ‘couching’ was used. This procedure involved using a sharp instrument, or just blunt pressure, to detach the cataract-riddled lens from where it normally resides into the back of the eye. Not surprisingly, this procedure was usually massively unsuccessful: patients usually suffered pain (as this was before a lot of modern anaesthetics were available), inflammation, infection and even blindness as a result. Even if the procedure and aftercare went smoothly, the patient was still left with inadequate eyesight. Unfortunately, couching is still performed in some developing countries where access to healthcare is often restricted.

As general surgical practice improved over the centuries, better tools and instruments were developed that allowed the opaque lens to be either removed, or broken up into small, more easily absorbable pieces. More often than not, patients were still left with poor eyesight and had to wear cumbersome, thick glasses to compensate for the missing lens.

Gordon Cleaver flew a Hurricane, the windshield of which was made from Perspex. Image from Tony Hisget, Wikicommons

Dr Harold Ridley, a recently trained medical doctor who specialised in ophthalmology, worked in the south of England during the Second World War. In August 1940, Flight Lieutenant Gordon ‘Mouse’ Cleaver forgot to put on his flight goggles before going out in his plane for what was to be Adlertag (Eagle Day) – the first day of Luftwaffe’s mission to eliminate the Royal Air Force from the sky. On returning to base, a bullet went through the side of Cleaver’s cockpit and shattered the Perspex window, a small fragment of which entered his eye. Cleaver had many operations on his face to treat the damage, but Dr Harold Ridley’s operation was to change medical history.

When Ridley removed the Perspex from Cleaver’s eye, he observed that there was no inflammation: the body hadn’t recognised the material as ‘foreign’ and so hadn’t initiated an immune response against it (as it usually does against materials like wood or metal). Ridley started thinking: if you could take the Perspex out of eye and there was no inflammation, then there would surely be no biological reason why you couldn’t put it back in.

A modern intracoular lens. The two arms help to fix the lens in place within the eye. Image from Wikicommons.

With this in mind, Ridley developed the first intraocular lens (IOL) – a small disc made from Perspex – and in 1949 placed it into the eye of his patient after first removing her cataract. With further modifications to improve the IOL’s power (that is, the ability of the lens to bend light, as glasses do), some of his first patients even attained 20/20 vision. Initially, Ridley sought to keep his patients’ implants a secret from the academic community until he could confirm from follow-up checks that there were no adverse effects, but a patient accidentally let slip the secret. So, in 1951 Ridley published his results and took two of his patients to be inspected by the Oxford Ophthalmological Congress. His work was rejected by other eye experts and deemed heretic. As a result, Ridley became a professional pariah and sank into depression.

Actor Robert Young had an IOL implanted that allowed him to carry on working. Image from Wikicommons

But not everyone was so sceptical about the IOL. Foreign eye doctors saw the promise of the invention and in 1974  – 25 years after the first IOL implant – a Club was started with the aim of discussing the use of IOLs in cataract surgery. Robert Young, a famous American actor, underwent the procedure and sang its praises to the press. Only years after he retired in 1971 was Harold Ridley officially recognised by the ophthalmic societies and institutions. In 2000 he was knighted by Queen Elizabeth, but he passed away in 2001.

The long-unappreciated work of Harold Ridley is now recognised as not just an invaluable contribution to ophthalmic medicine, but also one of the first ever feats of bioengineering. Applying a scientific strategy such as using materials that are foreign to the body to fix a medical problem was previously unheard of, yet today we benefit from IOLs, dental implants and pacemakers to name just a few. Increasingly, bioengineering takes advantage of 3D printing and other advancing technologies and materials in the production of tissue grafts and implants that, like IOLs, will make such a huge difference to peoples’ lives.

A plaque commemorating Sir Harold Ridley’s achievement at St. Thomas’ Hospital, London. Image from Wikicommons.

Post by Natasha Bray

 

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The evolutionary quirks of Australian animals

800px-Reliefmap_of_AustraliaAustralia is home to many interesting phenomena, amongst them its weird and wonderful wildlife. 86% of plants, 84% of mammals and 45% of birds found in Australia are not seen anywhere else in the world.

Australia became separated from the rest of the world when it broke away from Antarctica between 85 and 30 million years ago. The isolation of Australia, combined with its harsh, arid climate has allowed for the evolution of unique species, each filling a particular ecological niche.

Australia’s unique flora and fauna make it one of most fascinating places in the world to biology. The following is a highly scientific* ranking of some of the extraordinary creatures found in Australia, and why they are fascinating to science**.

#5 : The Kangaroo

kangaroo

Credit: Louise Walker

Kangaroos are marsupials, meaning that the females have a pouch in which they will rear the baby kangaroo (joey). Marsupials are also found in North and South America, but are most abundant in Australia.

Famous for using their very strong hind legs to bounce across the Australian plains, the kangaroo and its smaller relative the wallaby use this bouncing to travel great distances, allowing them to survive in the harsh desert conditions of their home country.

There are many different species of kangaroo. The largest, the Red Kangaroo, can grow up to 6 ft 7 in tall.

There’s a persistent rumour that kangaroos are so named because the first Western explorers asked the native Aborigines what those bouncing things were, and the Aborigine replied with their word for “I don’t know”, this being “Can-ga-roo”. However, this is not true, the word “kangaroo” actually derives from “gangurru”, the native word for a Grey Kangaroo.

#4 : The Koala

koala

Credit: Louise Walker

Another famous Aussie native, the koala is found on the east coast. Despite appearances and the fact that it is sometimes called a “koala bear”, it is not a bear at all. It is a marsupial and, like the kangaroo, rears its young (also called a joey) in a pouch.

Koalas famously subsist on nothing but eucalyptus leaves which makes them very slow and lazy. Some people believe that the eucalyptus has a narcotic-like effect on the koalas, a bit like being stoned. But the koalas’ sedentary lifestyle is actually due to a lack of nutrition in its diet leaves; meaning that digestion takes up a lot of energy leaving very little left over for things like moving. With regard to its picky eating habits, the koala may seem a little like its non-cousin the panda, in that they both spend all day eating something which isn’t actually very nutritious. The major difference is that koalas are voracious breeders. When the male is ready to mate, he makes a noise which has been likened to “a pig on a motorcycle”.

As you can see from the picture, koalas have two opposable thumbs. This allows them to climb trees and grab small branches with ease. A recent paper has also detailed that koalas adopt their famous “tree hugging” pose to help them lose body heat.

#3 : The Little Penguin

penguin

Credit: Fir0002/Flagstaffotos, commons.wikimedia,org

The smallest breed of penguin in the world, the Little Penguin stands at 30-35 cm in height. Found only in Australia and New Zealand, these penguins famously participate in the “penguin parade” on Phillip Island, near Melbourne. The penguins spend up to a month at sea feeding, but some will return to their nests at dusk, often to feed their hungry chicks.

When the time comes to return from the sea, the little penguins have evolved a great survival technique – they form groups of 10-20 in the sea, then choose one unfortunate penguin who has to make sure the coast is clear. This scout penguin runs up and down the beach a few times to make sure there are no predators so that the other birds can return safely to their nests.

For more information on the little penguin colony on Phillip Island, Victoria, see this link.

#2 : The Inland Taipan

Photo credit: Bjoertvedt, commons.wikimedia.org

Credit: Bjoertvedt, commons.wikimedia.org

This snake gets the honour of being ranked number 2 because it is the most venomous snake in a country full of venomous snakes – which I think is quite a feat.

The title of “most venomous snake” was awarded to the Inland Taipan as its venom has the lowest LD50 score when tested in mice. This means that a very small amount of toxin is needed to cause death in 50% of subjects when compared to venom from other snakes. The Inland Taipan is also highly venomous when used on human heart cells in culture. One drop of venom is enough to kill 100 men.

Despite its highly venomous nature, the Inland Taipan is actually quite placid and rarely attacks humans. The world’s second most venomous snake, the eastern (or common) brown snake is generally more aggressive and has more fatalities to its name, according to this rather baffling Wikipedia list.

Although it is the most venomous snake in the world, the Inland Taipan is not the most venomous animal in the world. This honour is usually bestowed on the Box Jellyfish. Guess which country this comes from ….

Perhaps the need to be tough enough to survive Australia’s harsh environment may explain why the country contains an abnormally large amount of deadly creatures.

#1 : The Platypus

Credit: John Lewin, commons.wikimedia.org

Credit: John Lewin, commons.wikimedia.org

When the platypus was first discovered by early Western explorers, the scientists back home thought this duck-billed, beaver-like, egg laying creature was a hoax. The platypus and the hedgehog-like echidna (also Australian) are the only living examples of monotremes, or egg laying mammal. They are classed as mammals because they lactate and are warm-blooded (although actually their blood is cooler than most mammals).

Sequencing of the platypus genome in 2008 revealed that it shares genetic characteristics with birds and reptiles along with mammals. Because of this finding, monotremes are believed to have formed a separate branch on the evolutionary tree, very early into the evolution of mammals. This makes the monotremes especially fascinating to science because they give us clues about our evolution that no other animals can.

The reason that the platypus gets top ranking (as opposed to fellow monotreme the echidna) is the extra evolutionary level the platypus brings – the males have a venomous spur on their ankles which can cause severe pain and swelling in humans. This spur is believed to be used during fights between males for the attention of a female.

So there’s your number one weird Australian animal – frankly, what’s not to love about a furry mammalian bird-reptile which, when angered, will give you a nasty kick with its poisonous ankle?

*by “scientific” I mean “in my opinion”.

** this does not include the many varieties of spiders found in Australia for no other reason than I don’t want scary spider pictures on my blog.

Post by: Louise Walker

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Can a brain scan reveal your true age?

TWOFor as long as carnivals and funfairs have been around, there have been people who try to guess your age; a trick that often goes hand-in-hand with horror at the response. With our ageing population, which is most likely due to advances in medicines, treatments and our understanding of diseases, age is quite topical.

A recent study has shown that observing  the anatomy of your brain may be able to uncover your true age. A set of biological markers has been shown to accurately predict the age of a young person’s brain. So, if you have ever told a white lie about your age at the cinema to get a child’s ticket, or if you ever tried to trick shop owners into thinking you were 18 so that you could be served alcohol or cigarettes then this could soon be a thing of the past!

Previous studies have tried to observe aspects of brain structure and function with the aim of identifying whether there are common patterns and timings during the development of our brains. Although many studies have been unsuccessful in trying to show this, a study carried out by Timothy Brown at the University of California combined a range of parameters regarding the structure of the brain in order to assess its age. Using 885 subjects aged between 3 and 20 years, individuals were selected from a diverse range of races, educational backgrounds and economic statuses.

Children can develop – in terms of mental capability and maturity – unpredictably, but what is not known is the extent to which these differences are based on physical features of their brain, and or are due to psychology or environment.

Magnetic resonance imaging (MRI) was performed on each of the subjects to look at the internal structure of brains, of which 231 features were studied, including certain structures, the connectivity between different regions, and thickness or volume of different areas of the brain.

oNELarge variations in many of the measurements were observed that corresponded to the ages of the subjects. By combining the data from each of the measurements using a complex mathematical equation, an accurate ‘snap-shot’ of how the brain appears at each age during development was formed.  Although there were slight differences during development between brains of a similar age, the equation was able to correctly predict the age of a child to within a year, with an accuracy of 92%.

These findings indicate the presence of a developmental clock within our brain that produces a precisely timed development of brain structures throughout childhood.

Although these findings are incredibly interesting, aside from giving us insight into how our brains work you may be wondering what the relevance of these findings are. Whether we would be able to use the same technique to reliably determine the age of an adult by looking at the structure of their brain is another question. To be able to identify the true age of an individual has many advantages, but one of the most important clinical applications of this would be in observing whether a child’s brain is developing at a rate that is comparable to others of a similar age. It would also be useful in observing brain structures in individuals with autism, and other developmentally related disorders.

There are also non-clinical applications for this technique, such as cases where border staff need to be able to accurately determine the age of an individual without documents to be able to make a decision on whether to grant asylum. In the Olympic Games in Beijing in 2008, controversy arose when officials were unable to decide whether some of the competing athletes had entered the games illegally by lying about their age in order to compete.

To further this work, the study should address whether the anatomy of the brain is able to reliably predict age in subjects that have reached adulthood. If biomarkers are able to accurately predict our age even after development, then this could lead to rapid advances in the development of medicines for age and development-related illnesses.

Study: Neuroanatomical assessment of biological maturity – Timothy Brown et al. – Current Biology, September 2012.

Post by  Sam Lawrence

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In Defence of Parasites

In Defence of Parasites_elephantisisParasites have a bad reputation. These tiny creatures are responsible for some of the most visually horrifying diseases known. For example, a microscopic worm causes the grotesquely swollen limbs of elephantiasis, while a single-celled parasite, Leishmania, is capable of destroying a victim’s face. However, we humans often concentrate on the worst aspects of certain species – just ask your average wasp or spider – and there is much more to parasites than disease.  Many parasitic infections in fact cause little harm – if we die, so do they – and by concentrating solely on the diseases they cause we miss out on some fascinating underlying biology.

I remember arriving late for one of my first undergraduate parasitology lectures and being pleased to find the lecturer had not yet arrived either.  “Sorry I’m late,” he said when he appeared, “I was on the Tibetan plateau yesterday, looking for tapeworms in foxes”.  This lecture was my first glimpse into the ecology of parasites, and where the elegance and sheer complexity of their life cycles became apparent.  We all marvel at the epic journeys in nature, such as the great wildebeest migration across the Serengeti.  But compared to parasites, those TV regulars have it easy.  Strolling from one part of Africa to another, avoiding the occasional crocodile or lion? Simple.

The life cycles of parasites can be incredibly complex and quite ingenious.  These animals often need to jump between several host species to mature and reproduce and many have evolved amazing ways of completing these unlikely journeys.

In Defence of Parasites_miceToxoplasma gondii is a single-celled parasite that can infect a number of mammals, but which ultimately needs to find its way into a cat to sexually reproduce.  The most common intermediate hosts for Toxoplasma are rodents and the parasite has evolved the remarkable ability to alter the behaviour of these animals in order to maximise its chances of finding a feline.  A mouse or rat that becomes infected with Toxoplasma not only loses its natural fear of cats but can even become actively drawn to their scent, deliberately seeking out catty environments and thereby increasing its chance of being eaten and the parasite’s chance of transmission.

In Defence of Parasites_fluke wormThe Lancet fluke, a flatworm that infects the liver of grazing animals, is also adept at brain washing its host.  This worm has two intermediate hosts, a snail and an ant.  Snails become infected by eating infected animal droppings, after which the parasites develop into cysts and are released in the snail’s slime.  Passing ants then swallow these cysts as they graze on the slime as a source of moisture.  This cycle alone is a beautiful example just how complex parasites’ life cycles can be, but the really clever part comes next…

Following infection of the ant, the Lancet fluke begins to exert its mind control.  The ant’s behaviour becomes peculiar and, like Toxoplasma and its stupidly brave rodents, this behaviour is due to the parasite’s attempts to increase its chance of transmission.  In the evening the ant leaves its colony members and travels to the top of some nearby vegetation.  Once there, it clamps its jaws on tightly and stays until dawn, a ruse by the parasite to increase the likelihood of the ant being accidentally swallowed by grazing cattle.  Clever stuff, but the parasite is cleverer still.  When day breaks, the fluke senses the rise in temperature and relinquishes its control over its insect host, allowing it to continue with its usual anty chores.  This prevents the ant dying in the daytime heat, which would also kill its parasitic puppeteer.

In Defence of Parasites_taxo brainEven within a single host, parasites face extraordinary challenges.  A single individual may have to navigate blindly from the gut to the lungs, from the skin to the eye, or from the liver to the brain.  Tunnelling through organs and hitching a ride in our bloodstream, the travelling parasites must face a relentless barrage from our immune system.  Many have therefore evolved sophisticated ways of dampening down host immune responses to protect themselves.  They are in fact so proficient at this that many scientists believe the lack of parasitic infection in developed countries, and the loss of their calming influence on our immune system, has led to the observed increase in allergies and autoimmune diseases.  Indeed, deliberate infection with parasitic worms has actually been used to successfully treat many such disorders.

The complexity and elegance of parasites is often overlooked, but they are marvels of nature. Parasites can treat as well as cause disease, and can alter host physiology and behaviour; they form important parts of ecosystems and undertake journeys which, though microscopic, are unrivalled in nature.  A single individual must endure environments as diverse and hostile as the bottom of a pond, the gut of a snail and the tissues of a wildebeest. And yet who gets the David Attenborough treatment?

This post, by author Dr. Andy Turner, was kindly donated by the Scouse Science Alliance and the original text can be found here.SSA

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Pint of Science 3 day festival comes to Manchester!

Pint-of-Science-logo-with-glasses-528x746What better way to enjoy a sprinkle of scientific banter than down your local pub complete with pint in hand! For three days only, this summer we have enticed some of Manchester’s finest academic researchers out of the lab and into the pub to talk to you about their work. Events are taking place across Manchester on the 19th to the 21st of May and cover a wide range of topics, with enough variety to keep even the pickiest scientific dabbler satisfied. So have a look at our line-up and pick your favourite night, if you’re lucky you may even spot a brainbanker or two, but be quick tickets are selling fast.


Matters of the mind @ The Albert Club in West Didsbury – Click here for tickets

Monday the 19th: Mental health: breaking the stigma

1We’ve all experienced the feeling of being unwell with the accompanying trips to the GP, time off work and medication. Coughs and colds are common and well understood, but what happens when our minds become unwell? One in four of us will be affected by mental illness, the effects of this are no less real than a bout of the flu, but are often much harder to understand. Despite the extent of mental health problems, those affected still experience stigma and discrimination – a burden which can be even worse than the symptoms themselves. This evening, join Dr Rebecca Elliott and mental health experts from the University of Manchester for an evening of discussion where we hope to break down barriers and challenge stigma.

Tuesday the 20th : Understanding stroke.

2With around 152,000 strokes occurring in the UK every year, it’s never been more important for us to understand the ins and outs of this devastating condition. As part of the Stroke Association’s Action on Stroke Month, speakers from the University of Manchester and the Stroke Association will give us a window into the brain and the lives of stroke survivors. Professor Stuart Allan will introduce the workings of the brain, how strokes occur and what makes them so destructive, including how targeting inflammation could offer a brighter future for survivors. A real highlight will be provided by stroke survivor and nurse Christine Halford and her daughter Natalie who will offer moving first-hand accounts of what happens when a carer becomes the cared for. We will have an interactive activity provided by the wonderful artist Amanda McCrann to bring together a fascinating night of information and discovery.

Wednesday the 21st : The ups and downs of sleep and circadian biology (sold out)

3Have you ever wondered why it’s so hard to function when you just wake up or what really drives us to spend almost a third of our lives tucked up in bed? This evening we will address these questions and more as we explore the ups and downs of circadian biology. Join Professor Andrew Loudon and Dr Penny Lewis from the University of Manchester as they take us on a journey through the mysterious landscape of circadian rhythms and sleep. We will explore what makes our biological clocks tick, how our hectic 24-hour lifestyle affects our internal rhythms, how snoozing is vital to our memories and uncover the difference between morning larks, night owls and the indecisive humming bird with a live science experiment!


Understanding our bodies @ Solomon Grundy in Withington – Click here for tickets

Monday the 19th : Unlocking the Sense of Smell – The Scent of A Maggot

4Professor Matt Cobb’s lab studies how the sense of smell works. To do this they use a rather unusual animal – a maggot. You and I have about 4 million smell cells in our noses. A maggot has just 21, and by using genetics they can make a maggot with just a single smell cell. By studying the behaviour of these animals, and the electrical activity of their smell cells, we can understand how smells are processed in the nose and in the brain. Not only does a maggot have a brain, but the bits of its brain that process smells are also wired up just like ours. So by studying something as simple as a maggot we hope to understand how the sense of smell works in all animals, including humans.

Tuesday the 20th : Nanotechnology & the Role of graphene

5Manchester is leading the way in graphene research, with a nobel prize being given to two of its researchers in 2010. The material has some exceptional properties: tougher than diamond, stretchier than rubber, and better able to conduct electricity than anything else. It also has a myriad of possible uses: bendy touchscreens for mobiles, super-light batteries, artificial retinas, more effective drug delivery … and that’s just for starters. Graphene could become as much a part of our daily lives as plastic, and its implications will be huge!

Wednesday the 21st : Personalised medicine and the future of cancer treatment

6This talk will provide a fascinating introduction to personalised medicine, and the future of cancer treatment. No two cancers are the same. So, even patients with the same ‘type’ of cancer will respond differently to treatment. Personalised medicine aims to understand each person’s individual cancer at a molecular level, so doctors can match patients with the treatments that will work best for them. This aim of treating every patient as an individual is still some way off, but Professor Caroline Dive, from the Manchester Cancer Research Centre, will discuss how scientists in Manchester are playing a pivotal role in bringing forward this era of personalised medicine.


Chemistry and Physics @ The English Lounge in the Northern Quarter – Click here for tickets

Monday the 19th : Ocean circulation – the awkward bits

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The heat capacity of the ocean is around one thousand times that of the atmosphere, and the ocean circulation plays a crucial role in climate change. For long term model simulations one needs to average over space and time to make the computations feasible, but important processes happen over relatively small time and length scales. In this talk, Dr Gregory Lane-Serff will explain some of these processes, including mixed-later deepening, flow over sills and through straits, and flows of dense water into the deep ocean. He will show results from observations, and explain how insights from laboratory models can help our understanding – with some experiments for the audience to do!

Tuesday the 20th : A sonic wonderland

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What are the sonic wonders of the world? Trevor Cox, a renowned professor who engineers concert halls, has made a career out of eradicating bizarre and unwanted sounds. But after an epiphany in the London sewers, Trevor now revels in exotic noises – creaking glaciers, whispering galleries, stalactite organs, musical roads, humming dunes, seals that sound like alien angels, and a Mayan pyramid that chirps like a bird. Join him and discover what insights these remarkable effects give us into how sound is made, altered by the environment and perceived by listeners.

Wednesday the 21st : Waste not, want not – A Radioactive Reality

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Radioactive waste can be one of the most sensitive issues regarding the production of nuclear energy. However, are we too quick to jump to conclusions without considering all the evidence? Matt will talking about the preconceptions that most people have when they hear about radioactive waste and the scale of the problem in the UK. He’ll also talk about what we’re trying to do to solve the problem, while binding all these topics together with some anecdotes about his experiences regarding the topic.


Planet Earth @ Odder bar on Oxford Road – Click here for tickets

Monday the 19th : Unlocking ancient DNA

10Michael is a Royal Society University Research Fellow based in the Faculty of Life Sciences, University of Manchester. His main research interests are in the recovery of genetic information from extinct animals. Due to the age and environmental conditions of the remains of the more poorly understood species, this usually takes the form of cutting-edge techniques in proteomics. In this talk he highlights some of the key areas that ‘palaeoproteomics’ has helped improve our understanding of mammal evolution.

Hunting dinosaurs in the 21st Century…

Dr Philip Manning

Phil is Reader in Palaeobiology and Head of the Palaeontology Research Group at the University of Manchester. He is also an STFC Science in Society Fellow, a Research Associate at the American Museum of Natural History (USA) and a Visiting Scholar at the University of Pennsylvania (USA). In 2014 Phil was elected a Fellow of the Explorer’s Club (New York). His research is both broad and interdisciplinary with active research topics from biomechanics of dinosaurs to the synchrotron-based imaging of both extant and extinct organisms. He and his team have worked extensively in the Hell Creek Formation of South Dakota and Montana, but their field program also includes sites in South America, Europe, Asia, Africa and Australia.

Tuesday the 20th : Taking volcanoes to the IMAX

11Kate Dobson is a geologist who applies the latest cutting edge 3D and 4D imaging techniques across a wide range of geological research, to capture and quantify the spatially and temporally variable processes that control how our planet works. She has been at the University of Manchester since 2011.

From Core to Crust: A journey through the interior of the Earth

Michael Ward Broadley

Michael Ward Broadley is a PhD student at the University of Manchester, and his research revolves around the use of noble gases and halogens as tracers of volatile movement between the Earth’s geological reservoirs. Studying magmas erupted from deep within the Earth’s mantle, by means of analysing their unique geochemical signatures rich in primordial noble gases, it is possible to understand how the Earth obtained its volatiles. The theories that are being put to the test include impacts with primitive meteorites and solar wind influence, among other fascinating mechanisms. Michael is also a regular contributor to his research group’s outreach program.

Wednesday the 21st : Secrets of the Moon

13Katherine Joy is a senior research fellow at the University of Manchester SEAES. Her research focuses on studying the geological history of the Moon throughout lunar samples returned by the Apollo astronauts, and lunar meteorites that are found here on Earth. She analyses these samples in the laboratory to investigate their chemistry, mineralogy and age. With the contribution of data collected by satellites orbiting the Moon it’s possible to reveal its fascinating geological evolution, as well as explore the wider history of the Solar System. Her work may one day help guide people planning to send astronauts back to the lunar surface.

Cooking Up A Comet – Francesca McDonald

Francesca is a first year PhD student and her research concerns determining and comparing the volatile budgets of the lunar and terrestrial mantles. This will make us understand the volatile behaviour during the formation and evolution of Earth-Moon system. The rock samples she studies are Apollo lunar basalts and terrestrial komatiites. She also partakes in outreach work where she talk about comets whilst having her glamorous assistant Alex Clarke cook her up a comet.

Hope you see you there!

the Brain Bank Team.

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The Science of Procrastination

Procrastination, or ‘the action of delaying or postponing something’ is a widespread habitual weakness common to most people in the world (unless you are super human, then this article does not apply to you). Specifically, it involves the pursuit of activities that provide short-term gratification while simultaneously delaying any task which is particularly laborious or unpleasant. Procrastination often manifests as a coping mechanism for dealing with pressure and anxiety surrounding personal trials; for example revising for exam1s or writing a novel. Although procrastination has acquired the characteristics of laziness, avoidance and sloth; stressed out students may now take heart to learn that scientists are attempting to understand the neurological and psychological underpinnings of task avoidance and whether it may actually confer cognitively beneficial effects on intelligence, creativity and development.

From a psychological perspective, procrastination is a problem of self-control which leads the procrastinator towards behaviours that provide short-term relief by making a stressful or boring task immediately avoidable. Task avoidance may be easier to understand if we look at another model of self-control, for example, in a dieter. Before going to a restaurant the dieter may be set on not ordering dessert but, once the time comes, they may give in to the lure of a moist sticky toffee pudding. Inevitably, following this decision the would be dieter is likely to regret their choice and may be racked with feelings of guilt and self-hatred. This behaviour stems from a disproportionate preference for immediate gratification (a sugary snack) over, more beneficial, long-term rewards (better health) and is known as ‘systematic preference reversal’. These brief but powerful lapses in self-control govern the brain’s preference for behaviours that provide instant gratification and avoids pursuing goal-directed achievement.

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The amygdala brain region (highlighted in red).

Procrastination on a neurobiological level actually appears to be emotionally driven, stemming from an internal desire to protect ourselves from negative feelings associated with the fear of failure. The amygdala is a brain region which has been associated with mediating a diverse number of normal behavioural functions including fear, emotion, memory and decision-making and is also involved in a number of psychological disorders including anxiety and phobias. This complex aggregation of brain cells has also been implicated in the neurobiology of procrastination, due to its role in establishing what is known as the ‘fight or flight’ response. This physiological reaction is most commonly linked to situations involving a threat to survival, but has also been applied as an explanation for task avoidance and procrastination. When we start to feel emotionally overwhelmed by an activity that is particularly challenging, or by the accumulation of multiple demanding projects, the amygdala induces this fight or flight emotional reaction in an attempt to protect us from negative feelings of panic, depression or self-doubt. When the amygdala detects a threat, i.e. when you begin to panic about how much you have to do before your exam tomorrow, it floods your system with the hormone adrenaline. Adrenaline can dull the responses of brain regions involved in planning and logical reasoning, leaving you at the mercy of more impulsive brain systems which may convince you that sitting on facebook for the next few hours is really not such a bad idea, even though you have an exam tomorrow. Short term gratification, can immediately relax us and improve our mood via the production of the neurotransmitter dopamine. Dopamine has a major role in reward-motivated behaviour, indeed, most behaviours that make us happy increase the levels of dopamine in the brain. This is when emotional memory comes into play. Specifically, because the brain will stimulate you to repeat an activity that has increased your happiness (and thus dopamine levels) in the past. Therefore, the amygdala encourages you to pursue such behaviours, despite the seemingly short-term advantages of doing so.

Research by Laura Rabin of Brooklyn College also implicates frontal regions of the brain, involved in what is known as ‘executive functioning’, in the induction of procrastination. Executive functioning is a term that encompasses a number of different processes, including problem-solving, changing actions in response to new information, planning strategies for approaching and completing complex tasks and most importantly regulating self-control of our own emotions, behaviours and cognition. Despite only demonstrating a correlative link (i.e. it is unclear if changes in executive functioning directly cause procrastination), this study suggests that procrastination may emerge as a result of a dysfunction of the executive function producing systems of the brain.

But does procrastination deserve its bad reputation, or may task avoidance actually confer some benefit? Some studies suggest that day dreaming, a well-known form of procrastination, may in fac3t be beneficial in terms of the developing mind. Research, by Daniel Levinson of the University of Wisconsin-Madison, demonstrated that children who are regular daydreamers actually have better ‘working memory’, i.e. the ability to juggle multiple thoughts simultaneously than their less dreamy counterparts. Working memory capacity has been positively correlated with reading comprehension and even IQ score, and may represent a cognitive advantage in the ability to handle multiple complex thought processes all at once. Further to this, daydreaming and procrastination have been argued to be beneficial as a type of rest for the brain. However, these potential benefits remain highly controversial, and are obviously subject to individual trait and personality differences.

So, if you are reading this instead of revising, writing your dissertation, or composing a report, don’t despair. Neuroscience offers us several ways we can tackle our tendency to procrastinate.

As procrastination stems from a split second emotional reaction that represses our reasonable thought processes (i.e. to be productive) and yearns for a happiness boost, we need to train our brains to see the completion of a task itself as the dopamine-producing experience rather than the procrastination. So, we should be focusing on rewarding ourselves for completing steps of a challenging project, rather than punishing ourselves for not getting it done. If a reward (no matter how small) is in sight, the amygdala, and the rest of your brain will encourage working towards receiving that reward, and will therefore be less likely to initiate behaviours that will distract you from achieving your goals. As dopamine release is triggered by things that makes us happy, dividing your work into small sections with a reward at the end of each step may be beneficial, so for every chapter you read or 100 words you write, maybe reward yourself with a YouTube clip of a cat singing, or a sneezing panda?

eAnother key element of procrastination is that we often set ourselves unrealistic goals, and when we fail to complete these we panic – and so does the amygdala – setting in motion a series of neurochemical reactions that will, quite literally, stimulate us to do anything else but the task at hand. So, throw those unrealistic goals out the window, break your work down to smaller manageable pieces and make sure you reward yourself each time you complete one. Finally, if you start to panic about the enormity of the task ahead, stop, take a breather, and give your rational mind the time to remind you that there is light at the end of the tunnel and the less you avoid it, the faster you will get there!

Post by: Isabelle Abbey-Vital

Posted in Isabelle Abbey-Vital | 3 Comments